Glutathione

Glutathione research material, available in 600 mg and 1500 mg vials. For in-vitro research only.

• X-ray work on glutathione reductase crystals resolved two bound molecules in different conformations, one V-shaped and one extended, with the zwitterionic glutamyl end as the most tightly held part and a mixed disulfide forming with Cys58 in the reduced enzyme. [1]
• Copper-catalyzed oxidation followed biphasic kinetics, consuming one mole of oxygen per four moles of thiol with minimal hydroxyl radical in the first phase and producing hydrogen peroxide and hydroxyl radical at an increased oxygen consumption rate in the second, so the molecule can act as a prooxidant. [2]
• A glutaredoxin-1 fused redox-sensitive fluorescent protein equilibrated specifically with the glutathione couple and resolved nanomolar changes in the oxidized disulfide against a millimolar background of the reduced thiol, on a scale of seconds to minutes. [3]
• A cryo-electron microscopy structure of an ABCC family transporter bound to the oxidized disulfide shows the two halves of that substrate held differently, one in a tight pocket and one in a loose pocket. [4]

Compound

Glutathione

Purity

99.60% (HPLC)

Identity

Confirmed by MS

Appearance

White lyophilate

Presentation

600 mg · 1500 mg

Catalog / lot

RV-0042 / RV-24-0042-2

For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or supplement.

Review the laboratory, lot identifier, and reported results in this document. Keep the lot identifier with your research records.